Overview of Treatment of IgA Nephropathy
نویسندگان
چکیده
Immunoglobulin A nephropathy (IgAN) is the most commonly encountered primary glomerulonephritis and it usually follows an indolent clinical course. However, hypertensive patients with proteinuria and renal insufficiency at presentation and patients with severe histological involvement are at high risk to develop endsta-ge renal failure. There is no consensus for the treatment of patients with IgA nephropathy. In general, patients with normal renal function, mild proteinuria (<1g/24h) and mild histopathological involvement need only observation, whereas patients with heavy proteinuria, impaired renal function and moderate to severe histopathological involvement are candidates for specific treatment. Angiotensin converting enzyme (ACE) inhibitors and/or corticosteroids are used in patients with proteinuria between 1 and 3g/24h. Combinations of corticosteroids and cytotoxic drugs are given to patients with IgA nephropathy and deteriorating renal function or patients with a rapidly progressive course.
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تاریخ انتشار 2011